Dimethylformamide (DMF) is a clear liquid, miscible with water and most organic solvents. It is a common solvent for chemical reactions.

Pure dimethylformamide has a special odor, while industrial grade or deteriorated dimethylformamide has a fishy smell because it contains dimethylamine impurities. The name comes from the fact that it is a dimethyl substituent of formamide (amide of formic acid), with both methyl groups located on the N (nitrogen) atom.

Dimethylformamide is a polar (hydrophilic) aprotic solvent with a high boiling point, which can promote the SN2 reaction mechanism. Dimethylformamide is produced from methyl formate and dimethylamine. DMF is unstable (especially at elevated temperatures) in the presence of strong bases such as sodium hydroxide or strong acids such as hydrochloric or sulfuric acid, and hydrolyzes to formic acid and dimethylamine.

HCON(CH3)2+H2O → (CH3)2NH+HCOOH.

The main purpose

【Use 1】Used as analytical reagent and solvent for vinyl resin and acetylene.

【Use 2】It is an excellent organic solvent, used as a solvent for polyurethane, polyacrylonitrile, and polyvinyl chloride, and also used as an extraction agent, a raw material for medicine and pesticide dimeform.

【Use 3】Dimethylformamide is not only a chemical raw material with a wide range of uses, but also an excellent solvent with a wide range of uses. It can be used for wet spinning of synthetic fibers such as polyacrylonitrile fibers and synthesis of polyurethane; it can be used for making plastic films; it can also be used as a paint remover for removing paint; it can also dissolve some low-solubility pigments and make the pigments with dyes specialty. Dimethylformamide can be used for the extraction of aromatics, for the separation and recovery of butadiene from C4 fractions and the separation and recovery of isoprene from C5 fractions, and can also be used as an effective reagent for the separation of non-hydrocarbon components from paraffin . It has good selectivity for the solubility of isophthalic acid and terephthalic acid: the solubility of isophthalic acid in dimethylformamide is greater than that of terephthalic acid, and solvent extraction in dimethylformamide or Part of the crystallization, the two can be separated. In the petrochemical industry, dimethylformamide can be used as a gas absorbent to separate and refine gases. In organic reactions, dimethylformamide is not only widely used as a reaction solvent, but also an important intermediate in organic synthesis. In the pesticide industry, it can be used to produce chlordimeform; in the pharmaceutical industry, it can be used to synthesize sulfadiazine, doxycycline, cortisone, vitamin B6, iodine glycoside, repellent, pyrantel, N-formyl sarcoid, antitumor Amino acid, methoxy mustard, Bian nitrogen mustard, cyclohexyl nitrosourea, furofluorouracil, tranexamic acid, befenmethasone, megestrol, cholerita, chlorpheniramine and so on. Dimethylformamide has a catalytic effect in the reactions of hydrogenation, dehydrogenation, dehydration and dehydrohalogenation, which reduces the reaction temperature and improves the purity of the product.

【Use 4】 Reagents for non-aqueous solution titration, solvents for vinyl resin and acetylene, organic synthesis, photometric determination, gas chromatography stationary liquid (maximum use temperature 50°C, solvent is methanol), separation and analysis of C2-C5 hydrocarbons, and can separate normal , Isobutene-[1] and cis, trans-butene-[2]. Pesticide residue analysis. Organic Synthesis. Synthesis of peptides. For the photographic industry.